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Control mice were treated with 0.85% saline in water

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J Biochem (2009) 145(5):57584.10.1093/jb/mvp013 120 StaerkJDefourJPPecquetCLeroyEAntoine-PoirelHBrettIet alOrientation-specific signalling by thrombopoietin receptor dimers

It was FDA-approved in 1990 as a diagnostic agent and again in 1997 as a treatment for childhood growth hormone deficiency (brand name Geref)